Beihilfe. Beihilfeverordnung Baden-Württemberg (Verordnung des Finanz- und Great, there are no words found on that are used . /informationen-zur-niedersaechsischen-beihilfeverordnung-nbhvohtml. Saxony Land Labour Court (Landesarbeitsgericht Niedersachsen), 28 May 1, 2 Beihilfeverordnung NRW; VGH Baden-Württemberg, 18 December , 4 S.

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A new therapy mounts a double-barreled attack on leukemia, targeting not just the cancer cells but also the. Like striking an enemy camp directly as well as cutting off its source of food and other resources, the agent, called Oxi, poisons leukemia cells and destroys the blood vessels that supply them with oxygen and nutrients.

Bihilfeverordnung of the treatment in mouse models of acute myelogenous leukemia, or AML, is described online and in an upcoming print issue of the journal Blood. The researchers plan human tests of the drug at Shands at UF later this year.

Each year, more thanpeople in the United States are diagnosed with a blood cancer, and about 80 percent of them die of the disease because there are no effective treatments, niesersachsen to the National Cancer Institute.

Some AMLs return after initially successful chemotherapy, while others do not respond at all. In addition, chemotherapy is too toxic for some elderly people, so they need an alternative.

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Many treatments and studies focus on killing cancer cells, but very few target the microenvironment in which those cells grow. That means paying attention to blood vessels, bone marrow, growth factors and cell-to-cell interaction and binding.

Existing therapies that destroy blood vessels do so by targeting a growth factor called VEGF-A, but they are not effective long term at eliminating leukemia. To try to find a strategy that attacked multiple targets, the researchers tested Oxi, a novel blood vessel-disrupting agent.

In mouse models, Oxi killed leukemia cells in addition to destroying the blood vessels that fed and nurtured them. Rafii is not affiliated with the UF study.

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After Oxi treatment, however, the researchers found that a thin layer of viable tumor tissue remained that was fed by newly formed vessels. The cells supplied by those vessels showed increased expression of a growth factor, as is often found in oxygen-deficient areas.

To disrupt this secondary formation of blood vessels, the researchers blocked the growth factor VEGF by administering an antibody called bevacizumab after the blood vessel-destroying agent OXi The combined approach led to enhanced leukemia regression. The research, funded by the National Institutes of Health and the Leukemia and Lymphoma Society, has implications for both basic science and clinical research, as the results suggest that potential therapies must be screened against not only leukemia cells, but also the environment with which they interact.

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Karp pioneered the use of bevacizumab — the antibody used in the UF studies — after chemotherapy, which resulted in remission among patients with cancer that was resistant to chemotherapy or that had returned after treatment. Food and Drug Administration quickly gave its approval in April for a phase 1 clinical trial.

That means the treatment could be available by late nniedersachsen the start of to eligible study volunteers at Shands at UF, as soon as the researchers are able to obtain the necessary funding beihilfeverordnunv the trial.

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